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Applications
Creativity matters. Learn from customers how to turn the flexibility of the Nano-PlotterTM line into scientific progress. This list outlines only a few particular applications. Ask for further references!
Scientific publications of our customers in the microarray field are available on our resources page. Click here.
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Manufacturing of Chip-based Diagnostics and Point-of-Care Products with the Nano-Plotter Here we publish examples from different customers who successfully transferred their research into products for the diagnostic market. More... |
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Spotting of Arrays into 96-well Microplates Nano-Plotter NP2.x instruments can be configured for arraying into microplates. On request GeSiM deliveres special target decks and print heads More... |
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Arraying of PEDOT:PSS for Organic Light Emitter Diodes (OLEDs) Microdispensing of functional liquids is an essential step in production of organic electronics and organic light emitter diodes (OLED). This application note outlines the results of dispense experiments with:Poly(styrenesulfonate)/poly(2,3-dihydrothieno(3,4-b)-1,4-dioxin), also known as PEDOT:PSS. |
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Antibody Spotting (Array Calibration) A short application note, highlighting the good reproducibility of GeSiM's piezoelectric print technology in antibody arrays. (HTS Resources, San Diego, USA, GeSiM) |
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Cell Lysate Microarrays (Reverse Phase Microarrays) In contrast to "Standard arrays", lysed cells are immobilized on microarray substrates, creating arrays of "unknown" content (E.g. clinical samples). Subsequently, these arrays are incubated with a limited number of antibodies generating specific binding reactions in each spot. (Zeptosens (Bayer), Witterswil, CH) |
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In a passed research project the Nano-Plotter is applied to the automated synthesis of peptide libraries on a variety of different solid supports such as glass microcapillary plates. For the realization of microreactions the Nano-Plotter is particularly suited, as it is capable to perform dosage steps in the microlitre as well as in the nanolitre scale. These dosage steps can be performed highly reproducible at desired reaction coordinates in the nanoliter scale. (Research Center Borstel, GeSiM mbH, D) |
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A Multiplexed Immunoassay for Rapid Detection of Specific IgE in Allergy Diagnosis The assay is based on microspots arrayed on a capillary flow membrane with an inherent 3-dimensional structure. The microspots contain natural allergen extract, purified and recombinant allergens which are covalently immobilized. The allergen reagents are arrayed at density of up to 100 spots/cm2 on membrane, each spot being 250 µm in diameter. (Phadia AB, S) |
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Separated Glyocproteins from serum samples are arrayed and probed with multiple types of lectins to detect glycan structures present in the glycoprotein. (University of Michigan, Ann Arbor, USA) |
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Printing of organic Field Effect Transistors Beyond the Life Sciences, the Nano-Plotter opens up a lot. Low-cost flexible electronics with organic semiconductor materials calls for an easy and cost-effective patterning process. While contact printing, e.g. using reels, might be useful for large-scale production, ink-jet printing ensures high flexibility. (Dresden University of Technology, D, GeSiM) |
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Coating of Drug Eluting Stents The GeSiM Nano-PlotterTM has been extended by a motor
controlled rotor for the application of Micrograms of solved polymer on
cylindrical microstructures. This application notice shows how to
dispense Nanoliter amounts on stainless steel made coronar stents. |
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